Wearing a Continuous Glucose Monitor – some observations

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About a month ago, I started wearing a Continuous Glucose Monitor (CGM), an ingenious device that constantly displays your current blood glucose levels, updated every 5 minutes round the clock wirelessly from a subcutaneous sensor. This is a fairly new technology but one that I’m convinced – in one form or another – will be standard management practice in the near future. 
 
As with every new technology, I expect there will be rapid improvements down the road. For that reason there are significant pros and cons at this point.  Here’s my personal take on the current Medtronic system’s values and shortcomings.
 
I recently updated my insulin pump from an old Animas pump (IR1000) to a Medtronic 722 Real-Time for just this reason: Medtronic, uniquely, has incorporated the display for their CGM system into their insulin pump. In this way one unit serves two purposes, alleviating the need to carry a separate device. 
 
You get constant and frequent bg feedback – every 5 minutes, 24/7, approximately 280 readings/day.   In addition to your bg values (in mg/dl or mmols) it also displays a graph which shows you at a glance whether that number is rising, falling or level, a critical piece of information as we all know. It also tells you whether you are rising or falling precipitously with either one or two arrows pointing up or down. This trend information is probably its greatest strength. Knowing my bg is 85 mg/dl (4.7 mmols) is usually pretty good news… unless I happen to know I’m plummeting, at which point I need to eat something fast. You can also pre-set high and low bg levels where you’d like to be alerted. I have my high set at 200 mg/dl (11.1 mmols) and my low at 65 mg/dl (3.6 mmols). Whenever the sensor says I’ve dropped below or above these numbers it warns me with a beep or vibration (or I can turn it off). This can be handy at night for obvious reasons. 
 
I’m also going though considerably less test strips. During the first week or two I was probably using more strips than usual, as I couldn’t resist the temptation to constantly test and compare numbers. You do in fact have to calibrate the system with meter tests 2-4 times/day to keep its accuracy in check. Because you can look at either a 3-hour or 24-hour graph, it’s a great tool for tweaking your basal rates, particularly nighttime basals which you don’t normally see. 
 
I’ve found it to be a godsend when skiing on some very cold Montana days – you can actually check your bg without even taking off a glove! And you can easily check every 15 or 20 minutes to see how that lunch bolus worked out, when it peaked or whether you need more insulin. Plus, since the sensor is literally in your body (subcutaneous), it’s always warm and entirely unaffected by the cold. You just look at the display (your pump) and read the number. On the 4 days I’ve skied with it, unless I have reason to not trust the results, I don’t even bother doing a finger-stick. I’ll wait and do a “meter test” when I’m inside, my meter is warm and completely reliable and enter that value for a calibration. 
 
But it’s not perfect. Since you’re actually testing interstitial fluid and not blood directly, there’s a 15-20 minute delay from “real time” blood values (meter results) to sensor values. If your bg isn’t rising or dropping quickly it’s a non-issue. But if it is – as indicated by the sensor – you have to mentally take that into account. For instance, if the sensor reading is 150 mg/dl (8.3 mmols) with the graph ascending and showing 2 up-arrows, I’m probably more like 180-200. And speaking of accuracy, you need to learn when the values are accurate and trustworthy and when they’re not. It’s largely a matter of knowing when to calibrate and how often, something that takes a little figuring out. 
 
Then there’s the cost. At this point in the dark ages of diabetes, most insurance companies aren’t covering it. Mine finally is but it took some convincing. Otherwise the cost for the sensor/transmitter system plus 10 sensors is a whopping $1000 USD. The sensors themselves are $35/each and are only “certified” to be used for 3 days. Absurdly expensive!  But there are ways to extend the life of the sensors to make them affordable. Of the 4 sensors I’ve used, the shortest I’ve worn one is 5 days. The longest was 14 days. The amazing thing (to you pumpers out there) is they produce virtually no skin irritation compared to an infusion set. Since they don’t introduce anything under the skin, they’re apparently tolerated much better.  
 
Another down side is you end up wearing yet another subcutaneous “probe.” As a pumper for 8 years, I’d gotten used to one always being there. Now there are two. You also develop a fascination with micro-managing your bg with all this new data. You tend to check the display on your pump every 10 minutes like a teenager checking their damn cell phone. (I now wear my pump on a clip where I can check it easily rather than in my pocket). You also have the alerts – low bg, high bg, calibration reminders. Fortunately, they’re easily turned off if you’re aware of the situation and tired of being reminded your bg is high. If you don’t want the data, it can be information overload.  But I love it. 
 
Two things I’ve learned so far: 
·        To minimize or even eliminate the classic post-prandial rise in bg, do the obvious – bolus 15 minutes before eating. This is something I’ve always suspected but it’s nice to see it supported with the results visibly graphed out in front of me. During my sedentary work day, this is possible, in the mountains, it’s much easier said than done.
·        I’ve concluded that splitting your bolus is what your body secretly does all the time! Medtronic calls it a “Dual Wave Bolus,” Animas calls it a “Combo Bolus.” Regardless, it’s when you deliver some of your bolus immediately and the rest of it spread out over a certain amount of time. I now do this for 80% of my food boluses. With the delay in metabolism from meals with any significant fat component, it seems to cover the real carb load much better than one single blast at mealtime. Verifying this is where the CGM comes in handy. You can do a meter test 2 or 3 hours after eating but you’re still only getting snapshots. The CGM gives you a much fuller picture. 
 
Sorry for the long ramble. Any questions – please add a comment.
Jeff

Jeff, I have just started on the medtronic cgm (only been on the pump for a couple of months) and agree that it is stupid to have to change the sensor every three days. How did you manage to keep them going?  With some difficulty I can get the pump to see the old sensor as a new unit, but it only seems to last about 12 hrs and then will not take a calibration, then says bad sensor. I have tried both recharging and not recharging the transmitter. I did have a box of sensors that were time expired, June and now it's Nov . It seems to be tricky to get the pump to see a new sensor. I have just received the replacement sensors and I guess I will try one of them. They are expensive $41.00 ea here in Canada. As far as the comparison lag in readings goes I find it is greater when the BG is high, at normal level around 6-8 the finger poke seems to be close.

William,
 
I'm guessing the problem with not getting much more than the original 3 days/sensor has to do with their age.  Five months past "expiration" could be the reason.  From my experience, the pump will always accept a "start new sensor" and the only indication that the calibrations might be rejected is when the ISIG (input signal) levels drop consistently below about 8.  I rarely see that before 6 days.
 
The best forum I've found to pick up useful tips on Medtronic's CGM is: http://www.insulinpumpforums.com//index.php?showforum=18.  Browse through that and you'll find tons of info on maximizing days on sensors, timing calibrations, etc.  It's a GREAT site.
 
If you've only had a couple months on your pump, you're probably dealing with a good case of information overload.  My suggestion would be to step back and get your basals reasonably well tuned, then utilize the CGM to tweak things like night-time basals and bolus/carb ratios.  Experiment also with "dual wave boluses."  The tendency is to want everything fixed and working perfectly right away, but there's no way of getting there without a fair amount of trial and lots of error.
 
I've also found the sensor glucose/blood glucose gap greatest when bg is high.  Sometimes entering a calibration when bg is high will tend to minimize that gap.  Regardless, the trend is more useful (accurate) than the exact bg at that point. 
 
Good luck, stay in touch and see what you pick up from that forum site.
Jeff

That was a FABULOUS ramble, Jeff.  Thanks!!!  Just missed some gnarly photos to go with it!
 
I see amazing potential (this CGMS) as a tool for competetive athletes and cold-weather enthusiasts of all sort.  Have yet to use it multi-day in extreme cold, but my guess is that when the system is on --- there is no going back.  I am also very excited about the freedom (sorry for the cheesy word choice) that it will give me to go out on a solo overnight.  It allows for better control and "another" set of eyes....
 
Happy New Year, dp

Another set of eyes is a great way to look at it.  Although I didn't talk about it, I also fully expect it to lower my A1c without incurring more hypos, in fact hopefully heading off a few.  My last A1c was a respectable 6.3 so an improvement would be quite telling.  We'll see in a couple months.
Any movement with your insurance querry? 

The beaurocratic wheels of private non-profit health care are presumably "studying" my request.  Hopefully they will move one way or another.  Any decision, even denial (which I will appeal), is better than no word at all.
 
I can definitely see it from the health care HMO's/insurance co. perspective, too.  I think that for the majority of Type 1s out there, this tool is a waste of money.  Plus, I doubt whether the bulk of diabetes professionals could make a good decision about whether you are a good candidate to take advantage of (and weed through all the techie aspects) any CGMS.
 
Using less strips is something that the insurance company would love to hear as a benefit, but I even doubt Medtronic would like to make that kinda claim!
 
It's almost 60 degrees F in Evanston and I did a great 3-hour group ride this morning.  Seems like Madison is like the arctic compared to a few hours south, although the snow up there will likely all melt by tomorrow...
 
cheers

Jeff,
Just read your original post regarding CGM after searching the wed for info.  I've been a Medtronics pump wearer for almost 15 years and have never really gotten very good control.  You'd think after 37 yrs of the disease and being a registered nurse that this would't be the case.  I've tried to live my life like I don't have IDDM, working nights, scuba diving, traveling, all the normal stuff.
I'm a Veteran's Admin patient at the Seattle VA Medical Center and they approached me about the continous monitoring.  Thank goodness they provide my pump and all supplies and they will do the same for the monitor.  They have to order a new pump because I currently have a 515 which is not compatable with the monitoring system.  I will be the first VA patient in the region on the system, so I'm basically they're test case. 
After doing some research on the web I was beginning to look at this new therapy with a jaundiced eye.  Looked like a very intrusive device with marginal benefit.  Just what I needed, another device hooked up to me.  Does wonders for the self image, right?  But, then I read your ramble, as you called it, (and very worthwhile!) and I started to see real benefits to the system that would overcome the negatives.  Sounds like you're an active guy and have a better understanding of the diseae process than most diabetics.  So, I'm going to do it!  Don't know if it will work out, but you've convinced me it's worth a try, even if that wasn't your intent.  Does this mean I can blame you if I don't like it?  Just kidding.  I'll let you know how it works out.  May be a few months before it happens.  We're talking about the government here.

To the person who is going to be wearing the CGM as kind of a "test-patient" for the VA, please make sure if you are going to be their test case that you follow all of the guidelines for the CGM and give it a fair shake. It is already so hard to get insurance companies to approve new technology. It sounds like the VA may be basing the availability of this products to others on how much it helps you and your opinion on it. I'm sure as a registered nurse you already plan on doing all of this, I just want to stress how important it is though to give CGM a fair shake and use it properly.
I actually have just been approved for CGM after fighting to get it for over 2-years. I finally got different health insurance and they pay 80% of the copay for it and I am responsible for 20%. It's well worth it. I have brittle diabetes so it's pretty scary for me at times. The first day or 2 it felt wierd wearing the sensor, but I am getting used to it. It's kind of like when I had to get used to wearing my pump. The feature that I find to literally be a life-saver is the warnings it gives for low blood sugars. I have had multiple seizures in the middle of the night in the last few years, one so bad I bit through my tongue. The first night I wore the sensor I had an alarm go off that woke me up because my blood sugar was low. The next night I went to sleep for the first time in almost 20-years (how long I've had diabetes) without the fear of dying. I'm also not afraid to drive now and I've already been able to leave my house a lot more because I'm not afraid of something unexpected happening with my blood sugars. I really feel like CGM has given me a new lease on life. I really wish insurance companies would approve CGM for more diabetics, at least for those with complications.
I have to agree with the author of this post that overall there are far more benefits than negative aspects. I know for me there has been a little bit of a learning curve. The first sensor I used pulled out of me, so I had to put in a 2nd one. That one hasn't pulled out. I use Tegaderm coverings over it so it stays in place well. I also learned that it's better not to have the shell-looking piece taped too tightly against your skin or it will lower your ISIG number. Usually if I just a piece of cotton behind it, it will put it at the proper angle to fix that. I've been able to identify spikes in my blood sugar that I was having at night that I didn't know I was having because it dropped again before I woke up.
The biggest downfall I see is the expense, as mentioned. Plus I was also told that the sea-shell-looking piece only lasts about a year or so, so that will have to be replaced at a cost of about $1,000 a year (at least it comes with 10 sensors). Like others, I was told that even though the FDA only approves the sensors for 3-days, I have been able to wear them for at least 6. The represenative who worked with me said that they usually recommend 5-days. She showed me how to get it to think it's a new sensor. Basically, you just go into the sensor start menu and go to new sensor. It will find the old sensor just like as if it were a new one. I haven't had any problems with doing that so far. I think the only big downfall besides that I have run into is that I keep getting a "weak signal" message. I was told that the sensor has a range of about 6 feet, but I've found at times if I have it about 2 feet away it won't read it any longer. I try to keep my pump on the same side as the sensor now (jI was told to just be sure to wear the sensor at least 2 inches away from where your pump site is).
Jeff- Do you mind me asking where you wear your CGM sensors? I have worn a few on the side of my body, but I have found that they tend to be inconvenient when worn there. I don't want to wear them on my arms because I'm afraid my pump might not pick it up since I'm already having some problems with that sometimes.
One last thing, for anyone wearing a pump and who has CGM you can get even more of a benefit by using the Carelink software that Medtronics has too. There is a little USB device that you can buy that plugs into your computer and it will wirelessly read the date off of your pump. You can then get a bajillion different reports showing all kinds of graphs and trends. Doctors love it when you come into their office with these in hand.

Hi Katie,
 
I usually wear my sensors on my abdomen.  I realize this is prime real estate, shared with infusion sets, but overall it's probably the most reliably performing area and the most out of the way.  After reading quite a bit on sensor site locations (be sure to see the forum mentioned in the post) I've experimented a bit.  A surprisingly good area is upper thigh, about where your jean pockets are.  It surprised me because I hike and cycle a lot.  To my amazement, it didn't hardly affect the muscles there at all.  I typically stick in a new sensor before bed, then calibrate it 2-4 hours later when I wake up to pee during the night.  This time of inactivity allows any initial irritation to disappear.  I'm still finding some areas better than others although the cause-effect is still unclear.  I also find some sensors perform MUCH better than others, even out of the same box.
 
Jeff

rndiver,
 
Thanks for the comments.  I think you will find the CGM useful.  I'm sure you'll also find it a little intrusive, another thing to pay attention to but in the end, clearly a benefit.  In your case, I'd expect those benefits to be (1) a good means of tweaking your basal rates, especially nighttimers, and (2) a great window into what direction your blood sugars are trending.  Not that with this new information you'll always be able to prevent the spikes, but for the first time you'll at least see them coming.  At least 25% of my how-the-hell-did-THAT-happen readings end up being head scratchers; problems never solved.  With the other 75% I can usually backtrack and figure out what went wrong.  This will be a good tool for making that accessment. 
 
Once you get "plugged in" (sorry...) a great forum for tips on what works and what doesn't is http://www.insulinpumpforums.com//index.php?showforum=18.
 
Be sure to report back!
Jeff